State police say the semi was hauling about 41,000 pounds (18,600 kilograms) of amber honey along Interstate 80/94 through Hammond when the driver lost control and the truck overturned about 6 a.m. CST Wednesday after its front axle apparently failed.
At least four large containers of honey began leaking, and the overturned semi was also leaking diesel fuel.
The crash prompted the closure of three of the highway's eastbound lanes at Calumet Avenue in Hammond. Police urged motorists to avoid what they called the "sticky situation" and seek alternate routes.
Police spokeswoman Sgt. Ann Wojas says all eastbound lanes were reopened about eight hours after the crash.
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