Destin Barnes scored 13 points and David Bell grabbed 12 rebounds for the Dolphins (1-1), who led 18-8 after Santos' back-to-back 3-pointers and were up 45-20 at halftime.
Freddie Ward scored 26 points and Jordan Battle added 17 with 10 rebounds for Johnson University, which shot 34.8% from the field.
Jacksonville plays Bowling Green at home on Monday.
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