The Broward County Sheriff's Office said Wednesday in a news release that the unidentified man was approached by the women while at the slot machines at the Hard Rock Casino in Hollywood.
Security footage showed one of the women pouring a substance into a drink and handing it to the man.
The man told investigators he felt drugged and had trouble moving after taking the drink.
Investigators say the women then took the man back to his hotel room where he passed out.
When he awoke, he found his cash and watch missing.
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