Mompremier was 9-of-12 shooting in posting her 19th double-double this season and Emese Hof added 11 points and 11 rebounds for her ninth double-double this season.
Miami (21-5, 9-2) led by one after the first quarter then opened the second period with 13 straight points. Pitt's only points were a pair of free throws in the final minute to cut the deficit to 32-20 at halftime. Pitt missed all 10 field-goal attempts in the period.
Mompremier had six points in an 8-0 spurt to a 17-point lead midway through the third period and the Hurricanes remained comfortably in front.
Danielle Garven scored 13 points for the Panthers (9-16, 0-11), who made only 2 of 19 3-point attempts.
Miami, which was coming off a win over defending national champion Notre Dame, has won the last five meetings with Pitt and 10 of the last 11.
Pitt is still looking for its first win since defeating Duquesne on Dec. 29.
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